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KMID : 0377519830080030253
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Chung-Ang Journal of Medicine
1983 Volume.8 No. 3 p.253 ~ p.265
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Inhibitory Effect of Plasma Transglutaminase on Growth of Ehrlich Carcinoma
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Lee Kee-Byoung
Kang Sang-Kyoon
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Abstract
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Plasma transglutaminase plays an important role in would healing and in polymerization of collagen. Several reports have shown that interference with fibrin cross-linking can modify the development of tumor and tumor metastasis, for examples acquired factor Ⅷ deficiency accompanies a variety of malignant tumors. Recent studies revealed LETS protein is cross linked by plasma transglutaminase, and decreased quantity of LETS protein on the cell surface was noted in neoplastic transformation. Since the stabilizied clot is involved in wound healing, we attempted to find out whether clot stabilization influenced tumor growth. Local or intravenous injection of plasma transglutaminase were performed to the Ehrlich carcinoma mice, ten tumor growth and survival time were estimated by scheduled time table. Local injection of plasma transglutaminase yields predominant inhibitory effect of tumor growth with marked elongation of survival time in Ehrlich carcinoma mice, compared with control group. Contrary, intravenous injection of plasma transglutaminase group revealed no retarded tumor growth with slight elongation of survival time in Ehrlich carcinoma mice.
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